Classical Studies – Berlin-stay Thu, 23 Sep 2021 00:08:12 +0000 en-US hourly 1 Classical Studies – Berlin-stay 32 32 Lack of efficacy of single-mode therapies of action in COVID-19 therapy – How the lack of predictive power of preclinical cell and animal studies misleads developments – Haberland – – Chemical Biology & Drug Design Wed, 22 Sep 2021 23:33:19 +0000

The various experiences regarding the failure of the drugs tested in the fight against COVID-19 have clearly shown that there is at least a need to question the obligation to apply classic preclinical development strategies that require models of efficacy. cells and animals are tested before proceeding to clinical trials. Most animals are not susceptible to infection with SARS-CoV-2, which has led to experiments with unilateral replication of the virus in cells and the use of animal models that have little in common with the complex pathogenesis of COVID-19 in humans. Therefore, non-clinical development strategies were designed to meet regulatory requirements, but they did not really reflect the clinical situation. This has led to the search for effective agents in many cases misguided. As proof of this claim, we now collect the results of these required preclinical experiments and compare them with the results of clinical trials.

Two clear conclusions that can be drawn from the experience to date: benefit to patients under randomized blinded conditions. Our hypothesis is that the complex COVID-19 situation may benefit from multimodal drugs. Here, the molecular class of aptamers could be a solution.

Source link

Study examines whether music can improve memory in people with Alzheimer’s disease Wed, 22 Sep 2021 02:59:00 +0000

The main objective of the study, titled “The Mozart Effect and Memory in Patients with Cognitive Impairment (MEM-COG)”, is to determine whether music can be used to facilitate or improve learning in patients with cognitive impairment. people with mild cognitive impairment (MCI) or mild cognitive impairment. Alzheimer’s disease (AD). It will also examine which aspects of music are essential for establishing cognitive advantage. In other words, what types of music – relaxing or invigorating – and what times are most useful: for example, in the phase when we are learning new information or in the phase where we are recovering information that we have learned previously.

As Calabria, researcher at the Cognitive Neurolab of the Faculty of Health Sciences of the Universitat Oberta de Catalunya and holder of a doctorate in psychology from the University of Padua, said, “it is important to differentiate these two aspects. , as they involve different memory processes, and this study will determine at which phase music may be of greatest benefit. “It should be noted that there are already studies indicating that exposure to music may increase performance in tasks related to memory, learning and attention, but, specifies the researcher, “the majority of these studies involved healthy people and we do not know if the music could be a complementary tool to cognitively stimulate the people. people with memory deficits These neurodegenerative diseases are characterized by difficulty forming new memories, and music may be one of them. new learning.

It should be noted that there are already studies indicating that exposure to music can increase performance in tasks related to memory, learning and attention, but, as the researcher of the l ‘UOC,’ the majority of these studies were in healthy people and we don’t know if music could be a complementary tool to cognitively stimulate those with memory deficits. These neurodegenerative diseases are characterized by difficulty forming new memories, and music could be a way to help consolidate new learning.

Classical music is the most memory efficient genre

The study will involve patients from the Hospital de Sant Pau in Barcelona and Música y Alzheimer, a center in Barcelona specializing in the rehabilitation and cognitive stimulation of people with Alzheimer’s disease through music. In the first phase of the study, participants will perform memory-related tasks with classical music playing in the background. They will have to memorize unfamiliar faces and remember them afterwards. Calabria explains that classical music is used because “it is a kind of music that is characterized by being both relaxing and invigorating, and has been shown to be the most effective in stimulating memory. In addition, the fact that ‘it has no words means there is less interference that verbal information can cause to the content that participants will need to learn in memory tasks. ” The aim is also to use the same methodology as previous studies on the issue with healthy subjects.

In the second phase, the researchers will use music familiar to the participants (popular and folk music) to see “whether the fact that they like it more could strengthen their emotional facets and thus bring more benefits related to the memory”.

Music, given the lack of pharmacological treatments

Since currently available pharmacological treatments have a very limited effect on cognition, the availability of other types of therapies – such as music – which can improve the cognitive status of those affected is of crucial importance. . With the results of this research, Calabria and the rest of the research team hope to provide specific guidelines to help restore some of the memory lost by these people: what type of people can benefit the most from music, which type of music to use and how much of the learning process it needs to be played to achieve the greatest therapeutic benefits.

“The Mozart Effect and Memory in Patients with Cognitive Impairment (MEM-COG)” is one of nine UOC projects funded by the R&I programs of the Spanish Ministry of Science and Innovation in its latest call .


Universitat Oberta de Catalunya

Source link

21 currachs travel from Inis Oírr to NUI Galway for special exhibition Tue, 21 Sep 2021 11:00:53 +0000
Students Nidah Ahmad, Roscommon; Saorla Fenton, Limerick; Saoirse Gibbons, Leitrim; Faye Ní Domhnaill, Cavan in the Quadrangle, NUI Galway at the launch of a new partnership between the University and Áras Éanna, Inis Oírr. Credit: Aengus McMahon.

Twenty-one uniquely decorated currachs traveled from Inis Oírr to the NUI Galway campus to officially launch a new partnership between the Áras Éanna Arts Center and the university.

The special exhibition opened on Friday as part of Culture Night and features unique works by John Behan, Jennifer Cunningham, Ger Sweeney and Áine Phillips, among others.

The currachs will remain on display in the Quadrangle of NUI Galway for one month, the public being invited to visit them free of charge and without prior reservation.

The new partnership between the University and Áras Éanna will see them work together to promote the islands and more generally the West as places of culture, learning and research.

Artist John Behan RHA in the Quadrangle, NUI Galway with his currach sculpture to mark a new partnership between the University and Áras Éanna

A new fund has been established by NUI Galway to support staff and students who wish to travel to the island and use Áras Éanna’s facilities as part of their studies.

“I often use the metaphor of ‘currach full of fish coming to shore” from Máirtín Ó Direáin’s poem “An tEarrach Thiar” to describe the ingenuity and potential of our university community and our region, “said the President of NUI Galway, Professor Ciarán hÓgartaigh.

“I am delighted that 21 currachs have come to the campus to launch the new partnership between the University and Áras Éanna.

“We respect the unique language, culture and environment we share in the West of Ireland and we are open to working with Áras Éanna and the Inis Oírr community to promote this particularity as part of our life. university.”

Áras Éanna Artistic Director Dara Mac Aoidh said that after a very successful summer exhibition at Inis Oírr, they are delighted to bring the “Curacha” exhibition to NUI Galway.

“We welcome this new partnership between the University and Áras Éanna, and look forward to working on many collaborations and projects in the future that will benefit both the University and the island of Inis Oírr” said Dara Mac Aoidh.

NUI Galway and Áras Éanna officially launched the exhibition, coinciding with the National Culture Night celebrations, in partnership with Galway Music Residency.

As part of the launch, ConTempo Quartet performed a specially selected suite of ocean-related classical and contemporary music, composed by Alec Roth, Claude Debussy and Katharina Baker.

NUI Galway drama students were also on hand to recite a selection of poems by Máirtín Ó Direáin.

The 21 currachs exhibition will run until October 10, 2021.

Source link

At 75, the Ojai Music Festival remains focused on the future Mon, 20 Sep 2021 20:07:43 +0000

OJAI, Calif .– The return is a process. It is rarely linear.

The Ojai Music Festival, for example, returned September 16-19 to celebrate its 75th anniversary after a long pandemic absence. But there have been setbacks among the returns. Compromises were made to accommodate her move from spring to the last days of summer. An artist has been detained in Spain by travel restrictions. Diligently enforced security measures have slightly hardened the mood of this historic event, a harsh yet relaxing haven for contemporary music nestled in an idyllic valley of impassive mysticism and sweet Pixie tangerines.

This edition of the festival is the first under the leadership of Ara Guzelimian, back at the helm after a race in the 1990s. Each year, the person in his position organizes the programming with a new musical director; For Guzelimian’s debut, he chose composer John Adams, the paterfamilias of American classical music, who just happens to be born in the year of the first festival. Uninterested in a retrospective for this milestone anniversary, they presented their concerts as a prospective survey of young artists, which befits a festival that has long focused on the future.

But in music, the past, present and future always inform each other. Bach and Beethoven haunted new and recent works; pianist Vikingur Olafsson treated Mozart, as he likes to say, as if the ink had just dried on the sheet music. There is no future without looking back.